Lumen Bioscience
Biologic drugs reimagined

Biologic Drugs Reimagined

Lumen unlocks the full potential of biologic drugs, whose promise has been held back by the lack of scalable technology. Our goal is to transform the way such drugs are developed, what they cost, and who has access to them.

How we innovate image

We've Reinvented How Biologic Drugs Are Made

Lumen's patented technology allows us to use the well-known food algae spirulina to deliver therapeutic proteins. It is also useful for important applications in human and animal nutrition.

Speed and safety

Unrivaled Speed with Safety and Efficiency Advantages

Our patented technology allows us to develop biologics faster with lower cost and greater potential for risk reduction than traditional methods.

$150M
Invested to Date
34
Issued Patents
24
Other Patents Pending

How It Works

Step 1: The Organism

Because spirulina cells are extraordinarily high in soluble protein (>60%), they can express much higher amounts of therapeutic proteins than any other food crop.

Illustration for The OrganismVisual representation of step 1: The Organism

Step 2: Bioengineering

A gene encoding the therapeutic molecule (for example, an enzyme, antibody protein, or cytokine) is introduced into the spirulina chromosome.

Illustration for BioengineeringVisual representation of step 2: Bioengineering

Step 3: Production

The production system requires only water, salt, CO₂, and light, so it is inexpensive and highly scalable. The entire biomass is simply spray-dried to a fine powder.

Illustration for ProductionVisual representation of step 3: Production

Step 4: Delivery

This powder can be packed into dose-specific capsules. Most are shelf-stable at room temperature.

Illustration for DeliveryVisual representation of step 4: Delivery

Neglected No More

Traditional drug development has failed to address a broad swath of high-burden diseases—not because the need isn’t there, but because the tools weren’t built for the job. This has left massive markets hiding in plain sight. Lumen’s unique oral biologics platform is purpose-built to unlock these opportunities with speed, precision, and affordability—disrupting entrenched models and redefining what’s possible in modern drug development.

C. difficile

C. difficile
$8B
problem for US hospitals annually
2.3%
of all US hospital costs annually

IBD

IBD
3M
Americans currently living with IBD
ZERO
approved therapies

Metabolic Disease

Metabolic Disease
No. 1
cause of death in the world
47M
Americans living with metabolic disease

Traveler's diarrhea

Traveler's diarrhea
50M
travelers at risk annually
29%
affliction rate in US servicemembers

Pipeline

Our lead program is LMN-801, a potential first-in-class oral product for weight loss

Core pipeline

  • Weight loss (LMN-801)
    Oral hormone protein
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)

    Weight Loss

    Product Candidate
    Weight Loss

    Mode of action:Oral hormone protein

    Phase 2

    A significant portion of the global population is overweight with rising prevalence and limited effective, safe, and scalable treatment options. LMN-801 is designed as a potential first-in-class, orally delivered biologic (a hormone protein) that targets metabolic signaling pathways to promote fat loss while preserving lean muscle mass—addressing key drawbacks of existing injectable therapies that often cause muscle wasting. If successful, it could fulfill the unmet need for a highly accessible, globally scalable treatment for overweight individuals.
  • C. difficile (LMN-201)
    Oral biologic cocktail
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)
    Partner logo
    Partner logo

    C. difficile Colitis

    (Clostridioides difficile)

    Product Candidate
    C Difficile Colitis

    Mode of action:Oral biologic cocktail

    Phase 2/3

    Traditionally considered a hospital-acquired infection, C. difficile is more commonly community-acquired today. Long-term consequences include chronic diarrhea, severe intestinal inflammation, surgical resection, and death. Insidiously, the very thing that is used to treat this infection—broad spectrum antibiotics—is also the thing that causes the disease. C. difficile appears near the top of the CDC’s antimicrobial threats list year after year. For these reasons, the orally delivered LMN-201 will be an important potential addition to the struggle against antibiotic-resistant infections.
  • IBD (Crohn’s/UC)
    Oral biologic cocktail
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)

    IBD

    (Crohn's disease and ulcerative colitis)

    Product Candidate
    IBD

    Mode of action:Biologic cocktail

    Preclinical

    Inflammatory bowel disease (IBD) is a systemic autoimmune disease, but it has an obvious nexus with the gastrointestinal tract. The two main sub-varieties—Crohn’s disease and ulcerative colitis—have many available treatments on the market today, but it remains a major unmet medical need: current treatments are costly, require inconvenient injection delivery, and often come with severe side effects. There are no approved advanced therapies at all for mild-to-moderate IBD. A safe, affordable, orally delivered drug to root out IBD at its source is a straightforward application of Lumen's technology, and would constitute a major advance for the field.
  • Oxalate malabsorption
    Enzyme
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)
    Partner logo
    Partner logo

    Oxalate degradation

    Product Candidate
    Oxalate degradation

    Mode of action:Enzyme dietary supplement

    Phase 2/3 ready

    Kidney stones affect millions worldwide, leading to discomfort, frequent recurrence, and costly medical procedures. Current preventive approaches are limited. Lumen’s novel oral biologic supplement is designed to support kidney and urinary tract health by helping maintain healthy metabolic balance and normal crystallization pathways. By promoting a favorable urinary environment, it may help reduce the risk of recurring stone formation. If validated through ongoing studies, this product could represent the first non-invasive, biologic-based nutritional approach for supporting long-term kidney wellness.

Innovation pipeline

  • Gastroenteritis
    Antibody cocktail
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)
    Partner logo
    CARB-X
    Partner logo

    Gastroenteritis

    (Various Etiologies)

    Product Candidate
    Gastroenteritis

    Mode of action:Antibody cocktail

    Field POC study planned 2026

    Acute gastroenteritis, caused by viral or bacterial pathogens, is a major global burden—especially in children and low-resource settings—leading to dehydration, hospitalizations, and even death. Lumen’s antibody cocktail is designed to neutralize the most common pathogens in the GI tract. Early field and ileostomy pharmacokinetic studies have validated delivery and local action; a proof-of-concept study in 2026 will assess effectiveness in real-world scenarios.
  • Viral Respiratory Infections
    Intranasal biologic
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)
    The Defense Innovation Unit Logo

    Viral Respiratory Infections

    (Influenza, SARS-CoV-2, etc.)

    Product Candidate
    Influenza & Covid-19

    Mode of action:Intranasal biologic

    Phase 1

    Viral exposure is a constant challenge, especially in shared environments where transmission risk is high. Traditional preventive measures are limited, and many people are looking for safe, non-invasive options to support their body’s first line of defense. Lumen’s novel intranasal biologic supplement is designed to help support the nasal passages—the body’s natural gateway—by maintaining a healthy protective barrier and promoting an environment unfavorable to viral attachment. By supporting localized immune balance and helping block environmental challenges at the point of entry, it may reduce the likelihood of person-to-person spread. If validated in ongoing research, this approach could represent a first-of-its-kind biologic-based supplement to support everyday immune resilience and transmission protection.
  • Malaria
    Intranasal vaccine
    MOA Previously Demonstrated
    Preclinical
    Phase 1
    (safety)
    Phase 2
    (proof of concept)
    Phase 3
    (definitive efficacy)
    NIH

    Malaria

    (Plasmodium infection)

    Product Candidate
    Malaria

    Mode of action:Intranasal vaccine

    Exploratory/Preclinical

    Malaria remains one of the world’s deadliest infectious diseases, with hundreds of millions of cases annually and rising resistance to frontline treatments and insecticides. Despite progress in vaccine development, coverage and durability remain limited, and affordable interventions are still urgently needed. If successful, this could provide a low-cost, stable, and easily distributed adjunct therapy for endemic regions—helping fill a critical gap in malaria control strategies.

Strategic Collaborations Expand Our Reach

Collaboration has helped get us to where we are today, and it is key to addressing the full range of opportunities that exist for mass-scale biologics.

Bill & Melinda Gates Foundation
National Institutes of Health (NIH)
The Rockefeller University
Foundation for Food & Agriculture Research (FFAR)
Naval Medical Research Center (NMRC)
Fred Hutchinson Cancer Center
University of Washington
NIAID (National Institute of Allergy and Infectious Diseases)
MassBio